STAGES OF VACCINE DEVELOPMENT

We would all agree quarantine has taught as many things in our life! How to live with the limited resources, the way it brought back to the health and hygiene of our old years , the understanding, attachment and love bonding of our family members in fast world , learning new courses, training, certificates, cooking ,regaining hobbies, Netflix, prime and so on …Well sometimes we also miss those daily suprising days , Yes we can’t schedule those days suddenly our mind calls for cheeseburger to grab it, those thalapakati briyani with our friends party , packing up things for a long trip in weekends and back on Monday morning with sleepless classes and office.In quarantine Morning to Evening we would switch different news channels but we hear the same news Corona, lockdown, Stay home where I hope you also heard this news vaccine is developed by US,UK, China ,India that’s all and then we don’t hear that news. What will be reason behind this news? Let us read in detail the procedure and the formalities of developing a vaccine.

What is Vaccine?

A substance used to stimulate the production of antibodies and provide immunity against one or several diseases, prepared from the causative agent of a disease, its products, or a synthetic substitute, treated to act as an antigen without inducing the disease. Simply Vaccination is a process of developing a immune system against a disease.

How vaccine works?

A vaccine works by training the immune system to recognize and combat pathogens, either viruses or bacteria. To do this, certain molecules from the pathogen must be introduced into the body to trigger an immune response.

These molecules are called antigens and they are present on all viruses and bacteria. By injecting these antigens into the body, the immune system can safely learn to recognize them as hostile invaders, produce antibodies, and remember them for the future. If the bacteria or virus reappears, the immune system will recognize the antigens immediately and attack aggressively well before the pathogen can spread and cause sickness. Source- Publichealth .org

Stages of Vaccine Development

The Resource and Development has major works in development of a new vaccine. They should firstly have look for the importance Vaccination in Publichealth. The vaccine must then be purchased, distributed, and used. Finally, a surveillance system is established to monitor immunization coverage, efficacy, and any adverse health effects related to vaccine administration.

There are 6 stages for the vaccine development

STAGE 1: PRIORITY SETTING : The decision making process of producing a vaccine to generated. To also know about the critique nature of the disease. Hence the vast resources will be collected to set up the common goal fo developing a vaccine in public and private sectors.

STAGE 2: BASIC AND APPLIED RESEARCH: The possibilities of developing a vaccine through the old traditional and fundamental way of medical practice in Development. The basic research is funded by the government and the authoritative scientists. Applied research indicates the involvement of the private hence that is funded by private concerns.

STAGE 3: CLINICAL EVALUATION:Good Vaccine must meet up the basic criteria of safety, purity, potency,efficacy. Here it involves the different phases 1, 2 and 3 . Animal checking and then to humans and brief description in the stage process of clinical evaluation.

STAGE 4: LICENSURE: Once the process is completed and the successfull news comes over the government would approve for licensing and to those government formalities rules and regulations are be formulated in this stage.

STAGE 5: PRODUCTION: Next stage of Vaccination is production it involves two major steps based on the requirements first one Pilot production where it rushes to produces for the pandemic . Second one scale up and full scale production where this method involves the full process of vaccine.

STAGE 6: RECOMMENDATION FOR USE: As the final stage of vaccine treatment the government will be recommend for the usage of this vaccine and dosage guidelines will be printed over it .

To be concluded that India has crossed the stage 3 of Development of vaccine in which the phase 1 of testing animals have gave the positive results and the Indian Medical research council have approved for human testing . Put you fingers crossed and hope this pandemic situation gets over and back to normal life.